Updates and Debate Concerning Margin Adequacy and Management following Breast-Conserving Surgery

Objective: Breast-conserving surgery (BCS) experienced a significant surge during the last decades due to increase of early breast cancer detection. Central discussion is margin adequacy which represents one most predictive factors for local relapse. This paper aims shed light on problem margins in surgery. Mechanism: We performed systematic narrative review literature by conducting search using Medline/PubMed, Scopus, and Embase. The following keywords were considered: “breast-conserving surgery” AND “margins”/“margin”. Findings Brief: In case invasive cancer, “no ink tumor” can be considered an adequate margin, while ductal carcinoma situ (DCIS), distance 2 mm from tumor should obtained. Many novel tools have been developed based both latest radiological imaging techniques tissue expression certain markers, with aim precise navigation excision intraoperative evaluation cavity margins. Oncoplastic oncologically safe improving cosmetic outcome patients’ quality life. appropriate use adjuvant treatments context multidisciplinary personalized management only means omit second intervention some carefully selected cases. Conclusions: Debate still exists concerning definition clear BCS DCIS. Further studies are required better assess multimodal treatment approaches this condition.